Bone marrow failure in children arises either from immune dysregulation or genetic predisposition. The advent of readily available germline and somatic genetic platforms now allow for an accurate diagnosis in the majority of children. Dr. Olson will discuss recent advances in the diagnostics and classification of bone marrow failure disorders. He will also discuss recent data regarding outcomes for patients with specific disorders, and how these data have led to recent changes in indications for HSCT. Finally, he will discuss recent clinical trial data exploring methods to make alternative donor transplant for bone marrow failure safer and more efficacious.
- Review an update on diagnostic approaches for inherited and acquired Bone Marrow Failure (BMF) syndromes
- Discuss treatment algorithms in Bone Marrow Failure, with an emphasis on HSCT indications
- Describe novel approaches to HSCT for BMF syndromes aimed at reduced toxicity and improving success
This seminar focuses on hematology and oncology and was delivered at a virtual event titled, “Curative Therapies for Bone Marrow Failure,” on August 18, 2021.
Additional CHOP Resources:
- Pediatric Comprehensive Bone Marrow Failure Center
- Cancer Center
- Upcoming Healthcare Professionals Events
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