Recent studies suggest that at least 10-15% of children with cancer develop malignancies as a result of a genetic predisposition. Some are identified by family history or physical features, but others are identified based on the type of tumor, multiple tumors, or genomic features of the tumor. Early identification of tumors in patients with genetic predisposition can dramatically improve outcome, as well as reduce the therapy needed and its associated toxicity, usually including avoidance of radiation. We have developed a pipeline to identify these patients, perform genetic testing, and recommend surveillance protocols to identify cancers early for those who test positive. We will present the general approach to patients with a possible cancer predisposition syndrome, review a few of the more common cancer surveillance syndromes, and discuss future directions in the field of pediatric cancer predisposition.
- Learn ways to determine if an individual may have a cancer predisposition syndrome if they do not have a cancer, or if they have a cancer.
- Become familiar with the more commonly encountered predisposition syndromes, and the cancers to which they are predisposes.
- Understand common surveillance practices to detect cancers early, when they are more easily curable, and what new surveillance tests are being developed.
This seminar focuses on oncology and was delivered at a virtual event titled, Cancer Predisposition and Surveillance in Children and Adolescents, on January 19, 2021.
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