Standard therapy for thyroid cancer in children involves surgical resection followed by radioactive iodine therapy in patients with invasive differentiated thyroid carcinoma.
Systemic chemotherapy has emerged as an option for care in adult patients, including tyrosine kinase inhibitors and oncogene-specific targeted therapy. There is an opportunity to incorporate these oral agents into clinical practice for pediatric patients with refractory, anatomically progressive disease after standard therapy has failed. There is also an opportunity for a paradigm shift where medical therapy with prior to surgery (neoadjuvant therapy) may maintain low-disease specific mortality and optimize outcome by reducing treatment-associated complications for patients that present with morbidly invasive disease at diagnosis.
This webinar reviews if and when these medications may be considered in caring for pediatric patients with advanced thyroid cancer and explores very rare tumors and developmental and advanced pediatric thyroid cancer therapeutics.
This seminar focuses on endocrinology and was delivered at a virtual event titled, “Advanced Pediatric Thyroid Cancer; is It Time for a Paradigm Shift in Care?,” on November 24, 2020.
Additional CHOP Resources:
- Pediatric Thyroid Center
- Division of Endocrinology and Diabetes
- Upcoming Healthcare Professionals Events
The work presented in the presentations, videos, and other content on this site (“Presentations”) includes publicly available medical evidence, a consensus of medical practitioners, and/or opinions of individual practitioners that may differ from consensus opinions. These Presentations are intended only to provide general information and need to be adapted for each specific patient based on the practitioner’s professional judgment, consideration of any unique circumstances, the needs of each patient and their family, the availability of various resources at the health care institution where the patient is located, and other factors. The Presentations are not intended to constitute medical advice or treatment, nor should they be relied upon as such. The Presentations are not intended to create a doctor-patient relationship between/among The Children’s Hospital of Philadelphia, its physicians and the individual patients in question. The information contained in these Presentations are general in nature, and do not and are not intended to refer to specific patients.
CHOP, The Children’s Hospital of Philadelphia Foundation and its or their affiliates, the authors, presenters, practitioners, editors, and others associated with the creation of the Presentations (“CHOP”) are not responsible for errors or omissions in the Presentations; for any outcomes a patient might experience where a clinician reviewed one or more such Presentations in connection with providing care for that patient; and/or for any and all third party content on the site or in the Presentations. CHOP makes no warranty, expressed or implied, with respect to the currency, completeness, applicability or accuracy of the Presentations. Application of the information in or to a particular situation remains the professional responsibility of the practitioner who is directly treating the patient.
To the extent that the Presentations include information regarding drug dosing, in view of ongoing research, changes in government regulations and the constant flow of information relating to drug therapy and drug reactions, the viewer should not rely on the Presentation content, but rather is urged to check the package insert for each drug for indications, dosage, warnings and precautions.
Some drugs and medical devices presented in the Presentations have United States Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the practitioner to ascertain the FDA status of each drug or device planned for use in their clinical practice.
You shall indemnify, defend and hold harmless CHOP, The Children’s Hospital of Philadelphia Foundation, and its/their current and former employees, officers, and agents, trustees, and their respective successors, heirs and assigns (“Indemnitees”) against any claims, liability, damage, loss or expenses (including attorneys’ fees and expenses of litigation) in connection with any claims, suits, actions, demands or judgments arising directly or indirectly out of your reference to or use of the Presentations.
The Presentations are protected by copyright laws and in some cases patent laws, and all rights are reserved under such laws. No part of the Presentations may be reproduced in any form by any means, or utilized in any other way, absent prior written permission from the copyright owner.
By starting this module, you agree to our Content Disclaimer and Terms of Service.
CHOP Employee? Log In Here
**By selecting “Yes”, you consent to receive information from CHOP. Once you have decided to receive such communications, you may later decide to stop receiving these communications. If you want to stop receiving these communications, you may send an email message to email@example.com.